: The effect of 8 weeks aerobic training on serum levels PTX3 and proinflammatory cytokine (IL-17) in patients with chronic kidney disease (CKD)
An increase in the inflammatory responses has been observed as one of the main causes of chronic kidney disease and it seems that regular physical activity can lower these reactions (1). This study was conducted to determine the effect of an 8 weeks aerobic training on serum levels of PTX3, IL-17,Cratinin and GFR in patients with CKD. The population consisted of CKD patients referred to Zahedan Emam ali hospital, who were purposefully invited to cooperate; of these, 60 CKD patients aged 30 to 50 years were selected and randomly assigned into two intervention and control groups. In this study, aerobic exercises were performed at 50–80% of the maximal heart rate (2). Blood samples were collected one day before of beginning of exercise and one day after the day, and serum interleukin-17and PTX3 levels was quantified in the laboratory using an ELISA kit (bendermed) manufactured by USA. The results of the study indicated a significant decrease in serums PTX3, interleukin-17,cratinin and GFR level after exercise (P> 0.05). These results support the finding that 8 weeks of aerobic training can lead to a significant reduction in the inflammatory index of interleukin 17, PTX3, Cratinin and GFR in CKD patients.
Keywords:PTX3, Interleukin 17, Cratinin, GFR , CKD patients, Aerobic exercises